Title: Scaffold Requirements Accordion

Biocompatibility

- Is the ability of a material to elicit an appropriate biological response in a given application in the body
- Is not a property of just a material, but rather a property of how a material reacts with its environment
- Does not induce an immuno response
- Does not reduce cell viability
- e.g. must be non-toxic and non-immunogenic
- Is the most fundamental requirement!

Porosity

- Open pores
- Fully interconnected geometry
- Highly porous provides a large surface and increases cell in-growth
- Adequate microporosity allows for capillary in-growth
- Porosity influences other properties (e.g. mechanical stability)

Pore Size

- Affects cellular penetration and neovascularization
- Ideal range for bone TE is 200-900 um

Surface Properties

- Affects cellular adhesion and proliferation
- Chemical properties e.g. polarity of the scaffold
- Topographical properties e.g. surface roughness

Mechanical Properties

- Ideally match the properties of bone
- Allows early mobilization