Title: Mechanotransduction accordian

1. Mechanocoupling

The conversion of physiological loads applied on tissues into local mechanical signals experienced by bone cells

2. Biochemical coupling

The process whereby cells sense a load using mechanoresponsive structures and transform it into a biochemical response

3. Signal transmission

The resultant downstream signaling within and between cells

4. Effector response

The response of osteoblasts and osteoclasts
The resulting cellular outcomes that lead to build-up, remodeling or resorption of bone matrix